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21.
22.
《Bioorganic & medicinal chemistry》2016,24(2):294-303
New cyclic RGD peptide-anticancer agent conjugates, with different chemical functionalities attached to the parent peptide were synthesized in order to evaluate their biological activities and to provide a comparative study of their drug release profiles. The Integrin binding c(RGDfK) penta-peptide was used for the synthesis of Camptothecin (CPT) carbamate and Chlorambucil (CLB) amide conjugates. Substitution of the amino acid Lys with Ser resulted in a modified c(RGDfS) with a new attachment site, which enabled the synthesis of an ester CLB conjugate. Functional versatility of the conjugates was reflected in the variability of their drug release profiles, while the conserved RGD sequence of a selective binding to the αv integrin family, likely preserved their recognition by the Integrin and consequently their favorable toxicity towards targeted cancer cells. This hypothesis was supported by a computational analysis suggesting that all conjugates occupy conformational spaces similar to that of the Integrin bound bio-active parent peptide. 相似文献
23.
We present a molecular dynamics simulation at 300 K in explicit solvent environment of chloroform of the stoichiometric complex formed by poly(alpha,L-glutamate) and octyltrimethylammonium ions. We observed that the alpha-helix conformation of the polypeptide chain remains stable during a 2-ns run. The surfactant ions predominantly adopted an extended conformation that is stabilized by favorable interactions with the organic solvent. Analysis of the organization of the surfactant with respect to the polypeptide chain indicated that each octyltrimethylammonium cation was preferentially bound to more than one carboxylate group. It was found that the most populated arrangement was that with the surfactant cations interacting with two carboxylate groups simultaneously. 相似文献
24.
25.
《Developmental cell》2022,57(5):610-623.e8
26.
为了揭示退化高寒草甸逆向转变的驱动因子,通过野外调查和室内分析相结合的方法探究了黄河源不同修复措施(施有机肥F、免耕补播N、施有机肥+免耕补播FN)处理高寒草甸植物群落特征、土壤理化性质和两者相关性的变化规律,阐明不同修复措施对黄河源退化高寒草甸植物群落与土壤养分的影响。结果表明:免耕补播显著增加草甸物种丰富度指数(P<0.05);施有机肥+免耕补播显著增加草甸植物盖度、总生物量、Shannon Wiener多样性指数和Pielous均匀度指数(P<0.05)。不同人工修复后草甸植物功能群地上、地下生物量变化趋势基本一致(除豆科)。和对照相比,莎草科,杂类草地上和地下生物量含量在N、FN处理分别降低83.04%、73.86%、30.43%、92.37%和96.51%、84.09%、85.68%、95.36%;禾本科地上和地下生物量含量在F、N和FN处理分别增加7.29%、23.45%、17.93%和6.04%、4.03%、10.52%;豆科地上生物量含量基本保持不变,地下生物量含量在F、N和FN处理分别降低24.43%、82.19%和42.61%。F显著增加土壤有机碳含量(P=0.033);N显著降低土壤NO3--N含量(P=0.009);FN显著降低土壤pH和增加土壤速效磷含量(P=0.024);F和FN显著增加土壤含水量(P=0.000),N则显著降低土壤含水量(P=0.000);F显著降低土壤容重(P=0.018)。相关性分析表明植物Shannon Wiener多样性和Pielous均匀度与土壤速效磷含量呈显著正相关(P=0.037;P=0.033),土壤有机碳和含水量与总生物量呈显著正相关(P=0.027;P=0.032),pH与盖度呈显著负相关(P=0.049)。冗余度分析结果表明土壤有机碳含量和含水量显著影响了植物群落结构特征,解释率分别为30.3%和19.7%。研究结果表明,因地制宜进行退化高寒草甸施有机肥+免耕补播修复措施,能够明显提高草地生产力,改善草甸植物群落及其土壤养分和水分环境。 相似文献
27.
Yun Guo Yuejun He Pan Wu Bangli Wu Yan Lin Minhong He Xu Han Tingting Xia Kaiping Shen Liling Kang Qiyu Tan Wenda Ren Yan Sun Qing Li 《Journal of Plant Ecology》2022,15(2):399
AM 真菌和枯落物互作下两种喀斯特植物种间竞争较种内竞争更能促进植物养分利用
枯落物是植物养分获取和土壤养分转化的关键载体。丛枝菌根(Arbuscular mycorrhizae, AM)对植物养分摄取的影响已被广泛认知。然而,在养分亏缺的喀斯特生境中,不同竞争方式的植物如何通过AM真菌和枯落物利用养分尚不清楚。本研究对两种喀斯特适生植物构树(Broussonetia papyrifera)和云贵鹅耳枥(Carpinus pubescens)进行种内竞争和种 间竞争种植处理,并通过幼套球 囊霉(Glomus etunicatum)接种或不接种处理,以及土壤中添加或不添加两物种叶片混合枯落物处理,测定了植物生物量以及氮、磷、钾浓度等指标,研究植物的生长和养分利用。研究结果表明,AM真菌对两种植物养分摄取影响不同,AM真菌显著提高了种内和种间竞争下构树的养分摄取量,但降低了云贵鹅耳枥的养分摄取量。种间竞争下接种AM真菌,枯落物添加促进了云贵鹅耳枥对氮的摄取,抑制了构树对氮的摄取。接种AM真菌和添加枯落物条件下,种间竞争的构树对氮、磷和钾的摄取量及云贵鹅耳枥对氮的摄取量均高于种内竞争;种间竞争下两物种养分竞争力呈现明显差异,即构树对磷和钾养分竞争力显著提高,对氮则不显著;云贵鹅耳枥仅对钾的养分竞争力显著降低,对氮和磷则无显著影响。这些结果说明,在AM真菌与枯落物相互作用下,两种喀斯特植物种间竞争较种内竞争更能促进植物养分利用。 相似文献
28.
《Journal of biological dynamics》2013,7(1):87-93
Populations may suffer unexpected loss or distortion of biodiversity as a consequence of strategies employed in artificial propagation programs. The Trinity River Fish Hatchery may have inadvertently experienced this while attempting to preserve diversity in a return time within a Chinook salmon population. We develop a model for this system and prove that the long-term distribution of return types converges and that it is strongly tied to the management strategy. Given estimates of heritabilities for return type and differential survival rates, an estimate of this long-term distribution can be computed easily. 相似文献
29.
Dynamical aspects of molecular dynamics (MD) simulations are analysed with a view to determining the nature of fast-ion conduction in δ-Bi2O3. The ratio P α of the moments of the self-correlation density distribution function, the velocity autocorrelation function (VAF), VAF integrals and VAF Fourier transforms, together with mean square displacement (MSD) data are interpreted in the light of experiment. It is shown that O2- migration cannot adequately be described by either the hopping or liquid-like models of conduction but is best regarded as belonging to an intermediate category. Analysis of the fine structure of the P α, MSD and VAF plots yields interesting correlations with vibrational modes. 相似文献
30.
Abstract In recent papers [1–3] we reported molecular dynamics simulation studies of ions and water molecules adsorbed in a rigid zeolite-A framework using a simple Lennard-Jones potential plus Coulomb potential with Ewald summation to investigate the structure and dynamics of the adsorbates. In the present paper the same technique is applied to study the local structure and dynamics of NH4 + ions in a rigid dehydrated zeolite-A. During the preliminary equilibration, the unstable NH4(4) type ion (the 12th ion) is pushed down to near a more stable 6-ring position in the α-cage that is already associated with an NH4(1) type ion (the 1st) in the β-cage, which moves to another 6-ring position in the β-cage that is already associated with an NH4(2) type ion (the 7th) in the α-cage. Calculated x, y, and z coordinates of some NH4 + ions are in good agreement with those obtained from an X-ray diffraction experiment except that no NH4(4) type ion is found and there are six NH4(2) type ions instead of 0.5 and 5.5 occupancy. The analyses of calculated interatomic distances and time correlation functions of these ions indicate that the NH4(1 – 1) and NH4(3) type ions are associated loosely with only one O (3) atom of the 6-ring and with only one O (1) atom of the 8-ring windows, respectively, while the NH4(1–2) and NH4(2) type ions are associated strongly with two or three O (3) atoms of the 6-ring windows in the α- and β-cages, respectively. The analysis of hydrogen bond time correlation functions of these ions indicate that about one, two or three, three, and one hydrogen bond of each NH4(1–1), NH4(1–2), NH4(2) and NH4(3) type ion is kept for 1.4, 21, 75, and 1.4 ps, respectively, before breakup of the hydrogen bond occurs and significant exchange of O atom hydrogen-bonded to the ion. 相似文献